Dr Guy Leschziner MA PhD FRCP


Peer-reviewed Publications

Drakatos P, Marples L, Muza R, Higgins S, Nesbitt A, Dongol EM, Macavei R, Gnoni V, Perez Carbonell L, Duncan I, Birdseye A, Dastagir S, Rosenzweig I, O'Regan D, Williams AJ, Leschziner G, Kent BD. Video polysomnographic findings in non‐rapid eye movement
parasomnia. J Sleep Res. 2018;e12772

NREM parasomnias: a treatment approach based upon a retrospective case series of 512 patients. P Drakatos, L Marples, R Muza, S Higgins, N Gildeh, R Macavei, EM Dongol, A Nesbitt, I Rosenzweig, E Lyons, Grainne d'Ancona, J Steier, AJ Williams, BD Kent, G Leschziner. Sleep Medicine, April 2018. Link

Clinical Update on Central Hypersomnias. Perez-Carbonell L, Leschziner G. Journal of Thoracic Disease, 2018, Vol 10 (suppl 1). Link

Obstructive sleep apnoea and Alzheimer's disease: In search of shared pathomechanisms. Polsek D, Gildeh N, Cash D, Winsky-Sommerer R, Williams SCR, Turkheimer F, Leschziner GD, Morrell MJ, Rosenzweig I. Neurosci Biobehav Rev. 2017 Dec 7. pii: S0149-7634(17)30435-9.

Effectiveness and side effect profile of stimulant therapy as monotherapy and in combination in the central hypersomnias in clinical practice. Thakrar C, Patel K, D'Ancona G, Kent BD, Nesbitt A, Selsick H, Steier J, Rosenzweig I, Williams AJ, Leschziner GD, Drakatos P. J Sleep Res. 2017 Oct 19. doi: 10.1111/jsr.12627. 

Phasic activity and the importance of irregular breathing. Drakatos P, Kent BD, Birdseye A, Dastagir S, Higgins S, Williams AJ, Leschziner G. Sleep Med, 25.07.2017.

Safety and efficacy of long-term use of sodium oxybate for narcolepsy with cataplexy in routine clinical practice. P Drakatos, D Lykouras, G D’Ancona, S Higgins, N Gildeh, R Macavei, I Rosenzweig, J Steier, AJ Williams, R Muza, BD Kent, G Leschziner. Sleep Medicine 2017, 
 http://dx.doi.org/10.1016/j.sleep.2017.03.028. Link

Functional Reorganization in Obstructive Sleep Apnoea and Insomnia: A Systematic Review of the Resting-State fMRI. Khazaie H, Veronese M, Noori K, Emamian F, Zarei M, Ashkan K, Leschziner GD, Eickhoff CR, Eickhoff SB, Morrell MJ, Osorio RS, Spiegelhalder K, Tahmasian M, Rosenzweig I. Neurosci Biobehav Rev. 2017 Mar 23. pii: S0149-7634(16)30713-8.

Evaluation of quality of life in adults with neurofibromatosis 1 (NF1) using the Impact of NF1 on Quality Of Life (INF1-QOL) questionnaire.
Ferner RE, Thomas M, Mercer G, Williams V, Leschziner GD, Afridi SK, Golding JF. Health Qual Life Outcomes. 2017 Feb 14;15(1):34. Link

Creation of an international registry to support discovery in schwannomatosis. Ostrow KL, Bergner AL, Blakeley J, Evans DG, Ferner R, Friedman JM, Harris GJ, Jordan JT, Korf B, Langmead S, Leschziner G, Mautner V, Merker VL, Papi L, Plotkin SR, Slopis JM, Smith MJ, Stemmer-Rachamimov A, Yohay K, Belzberg AJ. Am J Med Genet A. 2017 Feb;173(2):407-413.

Catathrenia, a REM predominant disorder of arousal? Drakatos P, Higgins S, Duncan I, Stevens S, Dastagir S, Birdseye A, Lykouras D, Muza R, Gildeh N, Rosenzweig I, Williams AJ, Leschziner GD, Kent BD. Sleep Med. 2016 Jul 20. pii: S1389-9457

Migraine with brainstem aura presenting as recurrent hypersomnia (Kleine-Levin Syndrome). A Nesbitt, G Leschziner. Practical Neurology, 2016 Oct;16(5):402-5.

Sleep-stage sequencing of sleep-onset REM periods in MSLT predicts treatment response in patients with narcolepsy.
Drakatos P, Patel K, Thakrar C, Williams AJ, Kent BD, Leschziner GD. J Sleep Res. 2016 Apr;25(2):203-10.

The Association Between Obstructive Sleep Apnea and Alzheimer's Disease: A Meta-Analysis Perspective. Emamian F, Khazaie H, Tahmasian M, Leschziner GD, Morrell MJ, Hsiung GY, Rosenzweig I, Sepehry AA. Front Aging Neurosci. 2016 Apr 12;8:78. Link

The utility of respiratory inductance plethysmography in REM sleep scoring during multiple sleep latency testing. Drakatos P, Higgins S, Duncan I, Bridle K, Briscoe S, Leschziner GD, Kent BD, Williams AJ. Respir Physiol Neurobiol. 2016 Apr 30;230:1-4.

Changes in Neurocognitive Architecture in Patients with Obstructive Sleep Apnea Treated with Continuous Positive Airway Pressure. Rosenzweig, I., Glasser, M., Crum, W. R., Kempton, M. J., Milosevic, M., McMillan, A., Leschziner, G.... Morrell, M. J. EBioMedicine. 10.1016/j.ebiom.2016.03.020. Link

Risk of Narcolepsy after AS03 Adjuvanted Pandemic A/H1N1 2009 Influenza Vaccine in Adults: A Case-Coverage Study in England. Stowe J, Miller E, Andrews N, Kosky C, Leschziner G, Shneerson JM, Hall A, Eriksson S, Reading P, Dennis G, Donegan K. Sleep. 2016 Feb 1. pii: sp-00484-15. Link

Cataplexy with Normal Sleep Studies and Normal CSF Hypocretin - an Explanation? Drakatos P, Leschziner G. J Clin Sleep Med. 2015 Nov 6. Link

Characterisation of sleep disturbances in postural orthostatic tachycardia syndrome: a polysomnography-based study. MF Pengo, S Higgins, P Drakatos, K Martin, N Gall, GP Rossi, G Leschziner. Sleep Med. 2015 Dec;16(12):1457-61.

Derived arterial stiffness is increased in obstructive sleep apnea and periodic limb movements during sleep. Drakatos P, Higgins S, Pengo MF, Kent BD, Muza R, Karkoulias K, Leschziner G, Williams A. J Clin Sleep Med. 2015 Sep 14. Link

Focal inhibitory seizures: a cause of transient recurrent weakness. FA Chowdhury, S Connor, RE Ferner, G Leschziner. Practical Neurology, July 2015 epub.

Bed Partner "Gas-Lighting" as a cause of fictitious sleep-talking. J Bashford , G Leschziner. J Clin Sleep Med 2015. June 11. Epub. Link

Prevalence and clinical presentation of headache in a national neurofibromatosis 1 service and impact on quality of life. SK Afridi, GD Leschziner, RE Ferner. Am J Med Genet A 2015, Jun 5.

Sleep Apnoea and the brain: a complex relationship. Rosenzweig I, Glasser M, Polsek D, Leschziner GD, Williams SC, Morrell MJ. Lancet Respir Med, 2015, 3: 404-414.

Update on Hypersomnias of Central Origin. P Drakatos, G Leschziner.  Current Opinion in Pulmonary Medicine, 2014. 20: 572-80.

Headache, drugs and sleep. AD Nesbitt, GD Leschziner, RC Peatfield. Cephalalgia, 2014. 34: 756-66.

Narcolepsy: a clinical review. G Leschziner. Practical Neurology, 2014. 14:323-31.

Insular seizures causing sleep-related breathlessness. A Nesbitt, CA Kosky, GD Leschziner. The Lancet, 2013; 382: 1756.

First REM period stage sequence in the hypersomnias. P Drakatos, SE Higgins, RT Muza, CA Kosky, AJ Williams, GD Leschziner. Sleep Medicine, 2013; 14: 897-901.

Sleep disturbance as part of the neurofibromatosis type 1 phenotype in adults. GD Leschziner, JF Golding, RE Ferner. Am J Med Genet A, 2013; 161: 1319-22.

Sleep stage sequence analysis of sleep onset REM periods in the hypersomnias. P Drakatos, A Suri, SE Higgins, IO Ebrahim, RT Muza, CA Kosky, AJ Williams, GD Leschziner. J Neurol Neurosurg Psychiatry, 2013; 84: 223-7.

Restless Legs Syndrome. G Leschziner, P Gringras. British Medical Journal, 2012; 344: e3056.

The NFTI-QOL: A disease-specific quality of life questionnaire for neurofibromatosis type 2. RE Hornigold, JF Golding, G Leschziner, R Obholzer, MJ Gleeson, N Thomas, D Walsh, S Saeed, RE Ferner. J Neurol Surg B Skull base, 2012; 73: 104-11. Link

Frequency of SMARCB1 mutations in familial and sporadic schwannomatosis. MJ Smith, AJ Wallace, NL Bowers, CF Rustad, CG Woods, G Leschziner, RE Ferner, DG Evans. Neurogenetics, 2012; 13: 141-5.

A restless night's sleep. D Athauda, G Leschziner. British Medical Journal 2012; 344: d8347.

An unusual case of hearing loss in a patient with neurofibromatosis type 1. G Leschziner, S Connor, SJ Wroe, RE Ferner. Clin Neurol Neurosurg 2012; 114: 735-7.

Q8IYL2 is a candidate gene for the familial epilepsy syndrome of Partial Epilepsy with Pericentral Spikes. GD Leschziner, AJ Coffey, T Andrew, SP Gregorio, E Dias-Neto, M Calafato, DR Bentley, L Kinton, JW Sander, MR Johnson. Epilepsy Research 2011; 96: 109-15.

Lymphomatosis cerebri presenting as a rapidly progressive dementia with a high methylmalonic acid. G Leschziner, P Rudge, S Lucas, T Andrews. J Neurol, 2011; 258: 1489-93.

Amyotrophic Lateral Sclerosis and Ocular Flutter. M Balaratnam, G Leschziner, B Seemungal, A Bronstein, RJ Guiloff. Amyotrophic Lateral Sclerosis, 2010; 11: 331-4.

Waldernstrom's-associated peripheral neuropathy and Bing-Neel Syndrome. G Leschziner, F Roncaroli, J Moss, RJ Guiloff. Muscle and Nerve, 2009; 39:95-100. 

The association between polymorphisms in RLIP76 and drug response in epilepsy. GD Leschziner, AL Jorgensen, T Andrew, PR Williamson, AG Marson, AJ Coffey, C Middleditch, DJ Balding, J Rogers, DR Bentley, D Chadwick, MR Johnson, M Pirmohamed. Pharmacogenomics, 2007; 8: 1715-22.

Complications of chronic therapy with antiepileptic drugs. MR Johnson and G Leschziner. Current Medical Literature Neurology, 2007; 23: 1-8.

ABCB1 genotype and PGP expression, function and therapeutic response: a critical review and recommendations for future research. G Leschziner, T Andrew, Pirmohamed, MR Johnson. The Pharmacogenomics Journal, 2007; 7: 154-79.

Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach. GD Leschziner, T Andrew, JP Leach, DW Chadwick, AJ Coffey, DJ Balding, DR Bentley, M Pirmohamed, MR Johnson. Pharmacogenet. Genomics, 2007; 17: 217-20.

Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study. G Leschziner, AL Jorgensen, T Andrew, M Pirmohamed, PR Williamson, AG Marson, AJ Coffey, C Middleditch, J Rogers, DR Bentley, DW Chadwick, DJ Balding, MR Johnson. Lancet Neurology, 2006; 5: 668-676.

Exon sequencing and haplotype analysis of ABC transporter genes implicated in drug resistance, and identification of haplotype-tagging SNPs. G Leschziner, D Zabaneh, M Pirmohamed, AJ Coffey, J Rogers, D Balding, DB Bentley, MR Johnson. Pharmacogenet. genomics, 2006; 16:439-50.

Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease. D Chan, NC, Fox, RI Scahill, WR Crum, JL Whitwell, G Leschziner, AM Rossor, JM Stevens, L Cipollotti, MN Rossor. Annals of Neurology, 2001; 4: 433-442.

Local learning of inverse kinematics in human reaching movement. P Haggard, G Leschziner, RC Miall, JF Stein. Human Movement Science, 1997; 16: 133-47.

Book Chapters

Restless Legs Syndrome. Sleep Disorders in Psychiatric Patients. Ed: H Selsick, Springer, 2018.

Neurology. G Christofi, G Leschziner, RS Howard. Oxford Pocketbook for PACES. Ed: R Bessant. Oxford University Press, 2012.

Sleep and the EEG. G Leschziner. e-Brain Project, 2012.

Narcolepsy. G Leschziner. e-Brain Project, 2012.